SCALABLE SINGLE USE SOLUTIONS

ABEC’s Custom Single Run (CSR®) product line is the new benchmark for single use implementation. Leveraging our long experience in equipment design, custom approach, and exclusive focus on production scale bioprocessing, the CSR sets new standards in single use performance:

• Maximum Process Flexibility
• Largest Production Volumes
• Lowest Cost of Goods
• Efficient Container Loading
• Robust Supply Chain
Bioreactor loading
ABEC 4,000 Liter Single-Use Bioreactor to Expand Emergent BioSolutions Manufacturing Capability
Emergent adopting ABEC Custom Single Run (CSR®) technology to increase flexibility and productivity

Bethlehem, PA, USA, October 24, 2017- ABEC, a global provider of integrated solutions and services for biopharmaceutical manufacturing, today announced that Emergent BioSolutions will equip their Baltimore, Maryland bulk manufacturing facility (Bayview), designated a Center for Innovation in Advanced Development and Manufacturing (CIADM), with an ABEC 4,000L CSR bioreactor. The system will be custom designed to Emergent’s process needs, operational requirements, and facility constraints, and will greatly expand cell culture capacity at the Bayview site.

THE VALUE OF
CSR® SCALABLE
SINGLE USE SOLUTIONS

MAXIMUM PROCESS FLEXIBILITY

CSR single use platforms are customized to meet a wide range of client’s needs. A clear process advantage of the CSR platform is seamlessly scaling or transferring to/from existing processes. Whether optimizing mixing and mass transfer for particular cell lines, arranging equipment to accommodate space and utility constraints or developing control systems to maximize productivity, customized CSR systems are designed and built to address process, facility, and operational requirements.

LARGEST PRODUCTION VOLUMES

The CSR product line leads the industry with bioreactor volumes up to 4,000L working volume, and liquid mixing systems up to 5,000L working volume; delivering significantly more product per unit area of floor space; a key metric in high-value multiproduct biopharmaceutical facilities.

LOWEST COST OF GOODS

The CSR brings true economy of scale to single use processing. Capacity is doubled within a similar footprint when comparing to the 2,000L systems currently on the market. Because equipment performance is comparable to stainless steel systems, high yield is achievable at larger scale.

ROBUST NON-PROPRIETARY SUPPLY CHAIN

Selecting materials used in the fabrication of the CSR-Disposable Containers (DC) is collaborative process, leveraging clients’ existing material qualification and validation efforts. Utilizing non-proprietary, commercially available materials, instruments, and components, the CSR DC offers flexibility of supply across different unit operations minimizing process, quality and supply chain risk. ABEC’s in-house, multi-site global manufacturing capability insures redundancy of CSR DC supply.

EFFICIENT CONTAINER LOADING

The CSR product line features innovative, safe and ergonomic solutions for packaging and handling of the CSR DC; even the largest container can be installed by one operator in less than an hour.

UPSTREAM/DOWNSTREAM APPLICATIONS

CSR Upstream

  • Bioreactor working volumes up to 4,000L
  • Fermenter working volumes up to 750L
  • Mixing and mass transfer, and control systems tailored to process requirements

CSR General Mixer

  • Harvest, Purification Pooling,
    Viral Inactivation
  • Large working volume capabilities up to 5,000L for high titer intensified processes
  • 10:1 turndown volume flexibility for low titer continuous processes
  • Full integration with filtration systems including pumps and sensors

CSR Buffer Hold

  • Multiple buffers each up to 4,000L
  • Stable buffer delivery at high flow rates
  • Reduced floor space and consolidated tubing runs
  • Self-deploying DC’s requiring minimal operator involvement

1974

Year ABEC Established

300,000 sq. ft.

Global Manufacturing Space

2

Disposable Container Clean
Room Manufacturing Sites

Up to 4,000L

Single Use Bioreactor
Production Volume Capacity

CUSTOMIZED SINGLE USE SOLUTIONS UP TO 4,000L

FAST DISPOSABLE CONTAINER LOADING

BIOPHARM ENGINEERING & PROCESS CONSULTING

DISPOSABLE CONTAINER GLOBAL MANUFACTURING

WHAT MAKES ABEC DIFFERENT

ABEC was founded 1974 at the dawn of the Biotech Era, and has been an innovative leader in biopharmaceutical manufacturing ever since.  Combining strong engineering and equipment capabilities, ABEC has successfully delivered thousands of projects, and many of today’s leading therapies are manufactured by processes and equipment engineered, designed, integrated, installed, and serviced by ABEC.

 

ABEC’s Unique Value

ABEC’s unique value is based on long experience, complete in-house capabilities, a custom, flexible approach, and long-term credibility. These factors, combined with our focus on partnering and repeat business, are essential to our long-term viability in a complex and highly dynamic industry.  Whether adding new capacity or improving existing facilities, ABEC is uniquely able to provide complete solutions that reduce overall cost and time to market while delivering maximum productivity.

BIOPROCESS ENGINEERING

Process Technology

Process Engineering

Equipment Engineering

Process Automation

3D CAD Design

EQUIPMENT MANUFACTURING

Single Use Systems

Cell Culture/Fermentation

Filtration/Chromatography

Solutions Preparation/Hold

CIP/SIP

Sanitary Vessels

INSTALLATION, COMMISSIONING & QUALIFICATION

Process Systems & Interconnect

Automation Integration

Factory & Site Acceptance Testing

IQ/OQ Protocols & Execution

PQ Support

SERVICE & SUPPORT

Process Scale-Up/Transfer

Upgrades/Retrofits

Troubleshooting/Repairs

Preventative Maintenance

Spare Parts Programs

Training & Education

Inquiries

For any inquiries or questions, please call
+1 610 861 4666, fill out the following form,
or email singleuse@ABEC.com.